Mikhail Blagosklonny Talks about Rapamycin

In the recent past, most people believed that aging was a functional decline occasioned by the buildup of indiscriminate molecular damage. They were of the opinion that it could not be prevented. The hyperfunction theory played a pivotal role in breaking this dogma. It described aging as the ongoing growth enhanced by signaling pathways like TOR (Target of Rapamycin). Notably, TOR-centric model is used to predict the rapamycin that can be beneficial to humans in terms of treating aging and preventing diseases. According to the article, “Rejuvenating immunity: “anti-aging drug today” eight years later,” Mikhail Blagosklonny posits that rapamycin can be used to prolong the life of a patient. Read more about Mikhail at LinkedIn

When used in proper schedules and doses, rapamycin and different rapalogs can be integral in enhancing the lifespan of humans. Most anonymous peer-reviewers and opponents ridiculed the theory. Mikhail posited that in 2008, predications indicated that five years later, the existing opponents of the theory would despise TOR-centric model. Recently, a study on Evirolimus (RAD001), which is an analog of rapamycin, made sensational headlines as it proved to improve the immunity of aging persons. Mikhail Blagosklonny posits that there could be the possibility that researchers are working on a “fountain of youth” drug that can enhance the health of older people and delay the outcomes of aging.

In 2006, Rapamune or Sirolimus, was approved to be used in the clinics. Mikhail posits that all aging-related diseases such as Alzheimer, osteoporosis, metabolic disorders, autoimmunity, cardiovascular diseases and cancer can be treated using rapamycin. He added that the drug would rank as the most useful anti-aging drug to prevent various diseases and slow down senescence. Mikhail contends that rapamycin is safe and can be administered on a daily basis to transplant patients for more than a year. Its pharmacokinetics have been researched properly. It has been found that rapamycin transforms the immunity of the users from aged-type to infant-type. To this end, it rejuvenates the immunity. This means that it does away with hyper-immunity instead of suppressing immunity.

Mikhail says that the well tolerated and non-toxic drug is safe for everyday oral administration. Clinical and preclinical data shows that rapamycin seems to have calorie-restriction-mimicking, bone-sparing and anti-tumor side effects. The drug has certain immunostimulatory activities. Many researchers have studied the drug and confirmed that it will become the pillars of anti-aging therapy in recent years. Until 2014, all studies showed that rapamycin would not be viable owing to its side effects. In addition, the use of the drug in this generation was considered fiction. Mikhail posits that rapamycin will be used in our lifetime. This information was originally mentioned on Impact Journals as highlighted in the following link https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4637294/

About Mikhail Blagosklonny

Mikhail is a renowned professor of oncology at the renowned cancer institute, Roswell Park. He is a graduate of the celebrated First Pavlov State Medical University of St. Petersburg. He has rendered his professional services at New York Medical College and Ordway Research Institute. His research focuses on anti-aging drugs, targeted cancer therapies, cancer and Biogerontology. Blagosklonny serves as an editor for Cell Cycle and Oncotarget. He loves to study about molecular and cellular biology, signal transduction, selective protection, cell cycle, mitosis and drug resistance for normal cells.

Learn more: https://www.ncbi.nlm.nih.gov/pubmed/?term=blagosklonny

The Growth of Fabletics

Fabletics is a company that has been successful and has not only found a niche within the world of fashion, but has also found a niche within the competitive industry of athletic gear that has been attracting more and more women to be healthier and to be more active on an everyday basis. Kate Hudson is the founder of Fabletics who created the company in order to offer women new selections for athletic gear that not only offer women a choice of high quality products, but that also offer women with choices that are stylish and inexpensive that will look great and that will not break the budget for any woman on a tight budget.

 

Kate Hudson is a woman who is always on the go. Kate Hudson is not only an actress and a model, but is also a mother who understands how hard it can be to wake up in the early hours of the morning and have to get ready for the day. With kids in addition to a career, Kate Hudson wanted to create a product that was not only meant to make her life easier, but was also meant to help make the lives of other women easier.

 

The company of Fabletics is a company that was created when Kate Hudson noticed the many gaps within the athletic gear industry. While looking at clothes to buy for herself, Kate Hudson noticed that either the clothes that she picked out were of good quality and expensive or were of low quality and inexpensive. As a result, Kate Hudson decided to make her own brand that took the best of both worlds and also added a unique style aspect that is a bit of her own personality coming out. Kate Hudson has made Fabletics to help improve the lives of women and to promote an active lifestyle.

 

What makes Fabletics such a unique experience is the fact that Fabletics tailors each of the clothing options to the preference of the buyer. All one has to do is visit the Fabletics website and take the quiz that tells the system to find the best outfit for not only the activity that it will be used for, but also the environment it will be used in as well as style preference. Kate Hudson has found a way to make shopping a relaxing experience that will not break the bank.

Roberto Santiago – The Owner of Roberto Santiago Manaira Shopping In Brazil

Roberto Santiago was conceived in Madrid, Spain in 1968. He pursued Sound and Image at the Faculty of Communication Sciences and Literary Creation of Madrid. Santiago has been an editor and a television screenwriter for marketing agencies in Madrid in addition to producing video clips and also has several published novels. Among them in the collection is Los Futbolísimos, which is an editorial phenomenon for children literature and one of the most best-selling in the country within the recent years, and has been translated into various dialects. Read more about the mall on exame.abril.com.

Several of his novels and works have also been honored such as the first book El ladrón de mentiras and winning of the Edebè Prize for kids literature. Other Santiago works entail The Suicide Club, The Longest Penalty in the World, At the End of the Road, among others. Santiago also collaborated as a screenwriter and director in various television series. The 58-year-old entrepreneur is the owner of Roberto Santiago Manaira Shopping In Brazil.

The Roberto Santiago Manaira Shopping was inaugurated in 1989 within the capital of Paraiba but has so far undergone various expansions since its construction. It is among the biggest shopping centers within João Pessoa and gives space for several other activities including entertainment and leisure activities. Santiago bought the land where the Manaira mall is in 1987 and established it for two years until it was ready. The mall comprises of rooftop concert hall, theater, food court, gaming area, gym, financial institutions, a college, and several shopping stores.

Inside the mall, there is the Domus Hall which is based at the rooftop of the mall and which opened in 2009. The Domus Hall has adequate space and hosts conferences, musical concerts, weddings, exhibits, fairs and graduation ceremonies. It can accommodate an estimate of 4,000 seated members and 10,000 standing individuals. The Hall is air-conditioned and soundproof and equipped with excellent sound equipment. The two-story structure is split into separate cabins; one in the upper for people in need of privacy and ground floor which is larger for public events. The hall has also alluded performances from local (Brazilian artists) and world artists from all corners of the world. Read more articles on Blog Do Gordinho

The Manaira shopping mall provides many entertainment alternatives including the movie theater that incorporates the most recent films. Likewise, it has a gaming space with a bowling alley with the food court having undergone various renovations in 2008, 2012 and 2014 to provide more dining stores with varying budgets for all. For that purpose, the restaurants have fast food places and high-end dining places such as Waynes, Espaco Gourmet and Capital Steakhouse. Roberto Santiago is also an owner of another mall referred as Mangeira which was established in 2013. The two shopping malls have contributed to the increased social and economic aspects of Joao Pessoa city.

EOS Lip Balm: A Yummy Spa for Your Lips

For those who have not had the chance to bask in the delicious and wonderful product that is EOS (Evolution of Smooth) lip balms, the product is a true innovator and absolutely amazing. All of their lip balms are infused with all-natural ingredients like jojoba oil, Vitamin E which is a powerful antioxident and shea butter. The lip balms are luscious and provide your lips with long lasting true hydration. They are also gluten free.

 

Seven years ago the company sprang up as a newbie in a highly saturated market. The incredible unique design along with the wide variety of fun and fresh flavors allows EOS to take over shelf space at major retailers like Walgreens.com and Target and soon celebrities were spotted pulling the little EOS balls out of their bags. The company has since expanded to lotions, shave creams and more, but at the heart of it is still the all natural lip balm and the use of quality ingredients. Continue reading here on blogwebpedia.com.

 

EOS lip balm keep their flavor line a delicate balance of truly wonderful flavors. Some of the top sellers are:

Strawberry Sorbert. This pink pot packs a delicious and fruity strawberry flavor that just flourishes with the feeling of spring. The strawberry flavor is delicate and not overpowering, perfect for spring or to refresh your lips in the summer heat. Click this link here now.

 

Sweet Mint. This mint-colored pot has the sweet flavor of icing mixed to perfection with a little kick of mint. This pot is perfect for those who want to refresh with a crisp minty scent after during a long day.

 

Coconut Milk. The coconut milk pot is part of the Visibly Soft line and has a creamy swirly on the EOS balm that denotes it is designed to give your lips maximum smoothness and a rich, silky feel. The coconut milk has a scent and taste like pure coconut, fresh from the rain forest and will leave your lips silky for hours.

 

Hop over this page, http://www.frenchtribune.com/teneur/25365-eos-lip-balm-secret-mastering-french-girl-beauty.

 

The Importance and Methods of Expanding Horizons

In this day and age, it is important to have an open mind. As a matter of fact, it is the people with open minds that are going to be successful in life. For one thing, people that are closed off about everything and put all of their eggs in one basket are more likely to experience a crisis in their lives because they are not open to more possibilities. One of the problems with some people who aren’t open to possibilities is that they believe that there is only one way to make things work. The truth is that with every possibility, there are sources of information that can help people learn how the possibility works.Learn more : http://www.wealthsolutionsria.com/blog

 

Among the sources of information is Richard Blair of Wealth Solutions. Richard is very experienced and observant about the possibilities that are available to people. He writes about all of the different ways to earn money. When people open their eyes, they are going to see tons of possibilities. The only thing is that many of the huge earners are going to require a lot of skill. Therefore, in order for people to be able to learn everything that is needed to become a success in their field of choice, then they are going to have to make sure that they have enough money to support them in the time they need for learning.

 

Richard Blair has a lot to say for all of the different ways of earning which include running an online business, affiliate marketing, renting or selling a home, investing and plenty of other ways to earn money. One thing that he stresses in his business is that everyone is different. Therefore, he is willing to help each of his clients find out what works for them the best so that they can have a much better chance at success.Learn more : http://www.wealthsolutionsria.com/p/my-story

 

Richard Blair encourages others to experiment in order to find something that works for them so that they will be able to succeed on their own merits and enjoy the journey while they are at it. Richard Blair definitely has the answers to all the needs of people.Learn more : https://www.crunchbase.com/person/richard-blair

 

CTRMA

Mike Heiligenstein and the Central Texas Regional Mobility Authority (CTRMA) are dedicated to improving the transportation infrastructure of Central Texas. Heiligenstein became the Executive Director of the agency the same year it became operational. Since then, it has grown into a nationally recognized leader in toll road operations.

Its work in Austin a couple of years ago proves its effectiveness. At the time the area was experiencing a rise in population and traffic congestion was steadily worsening. It was pretty apparent to the CTRMA that a tech solution was what the community needed. The agency makes an effort to blend technology solutions into their projects. the CTRMA is dedicated to building mobility solutions whether it’s a road or not.

It constructed the 183A toll road that helped to accommodate the influx of traffic due to population growth. The road spanned communities in both Cedar Park and Leander. It also built the the U.S. 290 toll road between Austin and Manor which impacted mobility greatly.

Preparations for the building of “smart roads” is well underway. The mobility authority is all about innovation. It’s no doubt that we’re only a few breakthroughs away from designing infrastructure that’ll be able to “communicate” with vehicles. The CTRMA already embeds fiber lines busy highways.

The CTRMA has collaborated with Metropia, an advanced platform allows travelers to discover and engage mobility options that optimize their travel and enhance their city’s sustainability, as well. The partnership has given birth to a mobile traffic app.

The app, working in unison with its traffic monitoring system, provides real-time alternative routes for commuters. On top of that, it also works with Carma, a respected carpooling app, that lowers the amount of commuters on the road. Learn more about Mike Heiligenstein: http://www.supplychaindigital.com/International-Bridge-Tunnel-and-Turnpike-Association/executives/Mike-Heiligenstein/31

The CTRMA has done much to to address the traffic woes in Central Texas, however, there’s still more work to be done. Of course, it knows it can’t cut out traffic congestion completely, but it has no problem continuing to try. Traffic is the concern of the agency, and it is more than happy to help residents beat the traffic jamz.

About Mike Heiligenstein

Mike Heiligenstein received his Masters of Government and Masters of Business Administration from the University of Texas. He is also a nationally recognized public speaker who’s been called to speak to groups about things such as transportation infrastructure.

Heiligenstein was a public official for 30 years. Throughout those years he has gained a reputation as someone with a strong commitment for using regional approaches to problem solving.

Bruno Fagali’s Rise to the Top of Brazil’s Attorney List

Bruno Fagali is a lawyer who calls Brazil, specifically the São Paulo area his home base. He has his Masters degree in State Law, Anticorruption, and Administrative Law. Bruno Fagali began his career as an intern for Model Dom Paulo Evaristo Arns. While he was working there, he focused on civil law cases involving domestic violence and family law. Over the next 3 years, Bruno Fagali went on to work at 2 other law firms, again concentrating on public law but expanding his knowledge in bidding and administrative contracts. In 2012, he was appointed his first attorney position with the firm Radi, Calil e Associados Law, where we worked for the next 2 years doing public law and administrative appeals.

The next chapter of Bruno Fagali’s life began when he became a Corporate Integrity Manager for Nova/sb, which is an advertising agency that is very pro-ethics. Nova/sb has won awards for using certain practices to help fight corruption. While working here, it was Mr. Fagali’s job to design and implement the Corporate Integrity program for Nova/sb, which he accomplished with his time there.

The newest venture in Bruno Fagali’s life is the opening of his new law firm Fagali Law in mid-2016. Bruno Fagali has been praised again and again for his outstanding commitment to his clients and achieving outstanding results in his cases. Bruno Fagali has built a reputation in Brazil and has entrepreneurs, organizations, and businesses that consult with him on their most complicated cases because they know he will get them the results they deserve.

Read this article to learn more about Bruno Fagali.

 

 

George Soros Re-emerges with Massive Support for Hillary Clinton

George Soros had left the political scene after his 27 million dollars contribution in an attempt to defeat George Bush in 2004 bore no fruits. He quietly reemerged as one of the top funders of democrats in addition to serving as conservatives’ bogeyman. During the campaign period, Soros committed more than 25 million dollars as a way of boosting Hillary’s bid in addition to supporting other democrats. This is something that the federal election commission says that Soros was able to achieve through his fundraising operations. The amount was expected to increase and Soros was expected to give even more as the elections neared. Learn more about his profile at Forbes.com.

Soros is a Hungarian born American who lived in New York. He had been friends with Hillary Clinton for more than two and a half decades, which was one of the reasons he prepared to attend his first democratic convention despite his advanced age of 85 years. He wanted to see his friend accept the democratic presidential nomination. This was however not to be since Soros felt that he needed to watch his trade carefully now that he had resume active trading. There was a need for him to keep a close monitor on the European economy hence he had to cancel his trip the last minute.

However, sources close to Soros reported that he was now politically active than he had ever been in his entire life. Some claimed that this could be stemming from his support for his friend Hillary Clinton or he could be operating from a fear of Hillary’s rival who Soros believes was busy instilling fear in people thus replicating the work of ISIS. A remark from Soros political advisor revealed that the level of engagement in democratic support was exceptionally high during the year because of the active election period. He might have been a consistent supporter of numerous causes the party undertook, but the level of interest heightened with the elections nearing. His interest was high long before Trump became the other side’s nominee. This heightened interest was brought about by the fact that Soros identified with the issues that the other side was against. These are the very issues he supports and cared about for years hence he had to support a democratic candidate to deal with matters of immigration reforms, religious intolerance as well as criminal justice reforms. Know more about George Soros on CNBC.

Those in the Clintons side viewed Soros move to support Clinton financially as a positive win. In fact, George Soros was seen as one of the influencers that could trigger other rich people to support Hillary’s bid. There are three elite donors including Tom Steyer, Fred Eychaner and Don Sussman contributed significantly in a number of other democratic campaigns. However, none of these people had the influence that Soros has in the political arena. However, the effect of this cumulative mobilization of funds by the elite in the society was a major boost for the Hillary Clinton campaign. This gave her an edge over her competitors especially as far as the campaigns were concerned.

Omar Boraie Development and Bringing Luxury to New Brunswick

Omar Boraie is an immigrant who built his business up from nothing. He started out with very little and chose to use that to make himself as successful as possible. This was something that he constantly worked hard to be able to do and something that he wanted to make a difference within the area that he was in. Because of all of the options that he had at his disposal, he knew that building up a real estate development company was something that he could do successfully. He also wanted to make sure that he could provide the city that he was living in with the boost that it needed.

The blog at Central Jersey Working Moms details all of the information about Omar Boraie and how he grew Boraie Development to become extremely successful. He wanted to see some changes being made to the area and that was something that he was confident in while he was building up New Brunswick. He also knew that it would be important to show people what he could do with his real estate development business. This was something that the Central Jersey Working Moms blog was extremely impressed with and they knew that it was due to the fact that he was a hard worker.

According to Patch, in the past, New Brunswick had crumbling buildings and was a destitute area. There was a lot of crime and more drugs than most people could imagine. Because of this, Boraie wanted to bring changes to the city so that people could enjoy it instead of having to be nervous about all of the crime. There were many different options that people could use but Boraie Development knew that the city would be so much better. Omar Boraie worked hard to make sure that New Brunswick was brought up out of poverty. There are now even luxury buildings scattered throughout the city.

Through all of this, Boraie has done what he can to make sure that he is giving back to the city. He has become very wealthy as a result of the development company but he works to give back to New Brunswick. He knows the city is only going to keep getting better and plans to be there for a lot of it. He wants to see the city grow and reach much lower crime rates due to the options that are now available.

See more: https://www.crunchbase.com/person/omar-boraie#/entity

 

OSI’s Chairman and Chief Executive Officer

Sheldon Lavin is the chairman of OSI Group, LLC. He is also the group’s chief executive officer. He is the president of OSI’s affiliate OSI International Foods Ltd. He is Rush University Medical Center’s general trustee and National Fish and Wildlife Foundation’s director.

Service
Sheldon Lavin has many accolades and serves on many boards. He is Ronald McDonald’s House Charities trustee, a board member for Goodman Theatre and also Rush University Medical Centre. Sheldon is also President of the Sheba Foundation. He is also the foundation’s director. This is a charitable family foundation.

Lavin’s Path
Lavin, who is now 81 years, still pursues the growth of OSI in Asia and Europe. Although the company has a presence in these continents, Lavin is still passionate about digging in and excellence. One would expect him to relax now that OSI has 55 facilities around the world, but Lavin sees potential for more business.

Like Sheldon Lavin on Facebook.

It was while working for Otto & Sons that his path to the meat industry became apparent. Otto & Sons were interested in building a factory for meat processing in the Midwest. This would help their ambitions to become the principal McDonald’s hamburger suppliers. At the time the problem was funding and when Lavin, though initially not interested in joining in as partner, joint the business, his contribution was remarkable.

When the Otto & Son’s proprietor retired, Lavin became a partner with the sons and he helped take the business overseas. While Sheldon Lavin was still working at Otto & Sons, though not permanently, McDonald’s requested he come in full time. Otto & Sons then changed to OSI and Lavin came in full time, growing the business impressively.

As an investor, banker and financial consultant, Lavin’s entry into the meat industry was strange. He had had a successful career in the financial industry. As chairman and chief executive officer at OSI group, he has grown the company from a simple McDonald’s supplier into a global supplier to multiple retail brands and food services. Now OSI Group LLC incorporates others such as OSI industries, OSI International, Incorporated and OSI International Foods.